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Amphetamine is thought to inhibit monoamine oxidase, whereas the ability of amphetamine and its metabolites to inhibit numerous P450 isozymes together with other enzymes hasn't been sufficiently elucidated. In vitro experiments with human microsomes reveal slight inhibition of CYP2D6 by amphetamine and small inhibition of CYP1A2, 2D6, and 3A4 by a